Probing the Mind-Body Connection

Polina Anikeeva develops cutting-edge neurotechnologies to probe the flow of information between the brain and peripheral organs in the body.

The brain and the digestive tract are in constant communication, relaying signals that influence our behavior and mental state. Anikeeva’s lab has developed ultrathin, flexible fibers that probe this extensive communication network. The multifunctional fibers are compatible the body’s soft tissue and are equipped with light emitters for activating subsets of cells and tiny channels for delivering genetic cargo or drugs. By deploying these probes within the gastrointestinal tract, Anikeeva’s team has explored how gut-brain circuits contribute to complex behaviors like decision-making and mood.

Anikeeva’s group is also developing magnetic nanoparticles to modulate neural activity wirelessly. Working in conjunction with biological receptors, these non-invasive nanoscale transducers could replace wires in deep-brain stimulation for Parkinson’s disease, or control stress hormones released by adrenal glands. Ultimately, Anikeeva hopes these novel technologies will improve therapies and predictive diagnostics for achieving healthy minds in healthy bodies.